An asymmetric structure of the Leptospira´s flagellar filament

Date and venue:  2024, February 22th al 10.00 CET.
B6 room- CNB/CSIC, Madrid

Summary Description:
Leptospira species, as all spirochetes, possess specially adapted endoflagella confined within the periplasm. Endoflagella are essential for the fast corkscrew-like swimming and pathogenicity of leptospires. However, little is known about the composition, function, and molecular architecture of these endoflagellar filaments. Through a combination of bacterial genetics, protein crystallography and cryo-electron microscopy/tomography, significant progress has been made in determining the 3D structures of complete Leptospira flagellar filament assemblies, revealing an asymmetric organization, comprising at least 14 different types of proteins.

Present by: Nicole Larrieux from Unidad de Cristalografía de Proteínas (Laboratorio de Microbiología Molecular y Estructural at IPM)

For more information, please contact Oscar Saiz at